Tumour necrosis factor-alpha and other cytokines in Guillain-Barre syndrome.

Tumour necrosis factor-alpha and other cytokines in Guillain-Barré syndrome.

The efficacy of plasma exchange implicates myelinotoxic humoral factors in the pathogenesis of Guillain-Barré syndrome. Candidate factors include autoantibodies to peripheral nerve myelin, which are not unique to Guillain-Barré syndrome; and cytokines such as tumour necrosis factor-alpha (TNF-alpha) which are T cell/macrophage products. Plasma cytokine concentrations were determined in 26 patie...

Circulating tumour necrosis factor alpha & soluble TNF receptors in patients with Guillain-Barre syndrome.

BACKGROUND & OBJECTIVES Tumour necrosis factor-alpha (TNF-alpha) is regarded as one of the immune factors that can induce demyelination of peripheral nerves in patients with Guillian-Barre syndrome (GBS). This present study was undertaken to find out the role of TNF-alpha and soluble TNF receptors in the pathogenesis of GBS; and to study the effect of intravenous immunoglobulin (ivIg) therapy o...

Tumour necrosis factor and other cytokines in murine lupus.

Investigations into the structure, expression and functional status of cytokines, as well as on the possible utility of their agonists and antagonists as therapeutic agents in lupus, have received prominent attention. In fact, mouse strains predisposed to lupus (NZBxW, BXSB, MRL-lpr) have long constituted the primary resource to investigate the role of cytokines in autoimmunity. An additional i...

The Guillain-Barre' syndrome.

EPIDEMIOLOGICAL, CLINICAL AND ELECTRODIAGNOSTIC FINDINGS IN CHILDHOOD GUILLAIN-BARRE SYNDROME

In order to identify the clinical and electrophysiological characteristics of childhood Guillain-Barre Syndrome (GBS) in East Azarbaijan province, clinical and electrophysiological data on 40 consecutive children with GBS, admitted to Tabriz Children's Medical Center from March 21st 1999 to March 20th 2002, were analyzed. All patients received intravenous immunoglobulin, 400 mg /kg/ day fo...